| Summary: | 碩士 === 長庚大學 === 醫務管理學研究所 === 97 === Stroke is the second leading cause of death in Taiwan for many years, and also resulted in long-term disability. Warfarin is an effective therapy for both the treatment and prevention of Stroke. However, the use of warfarin should be under close surveillance, or it may lead to bleeding, clog, or even death. Especially, in some drug interaction databases reported that concurrent intake of warfarin after stroke would cause serious drug-drug interactions. The aim of this study was to analyze the incidence and the related factors to gastrointestinal bleeding of concurrent use of warfarin and aspirin.
This study analyzed per warfarin prescribing period based on Taiwan Healthcare Insurance Database from 2001 through 2004. Cases were identified as warfarin taking stroke patients and at the end of each warfarin prescribing period followed up by 60 days to see whether the patients appear to have gastrointestinal bleeding or not. In addition, we analyzed the distribution of these concurrent used of warfarin and aspirin, including specialty and levels of medical institutions.
Results:
Total 724 warfarin prescribing periods, and there were 47 cases of concurrent warfarin and aspirin intake with gastrointestinal bleeding within 60 days after the end of warfarin prescribing period. Most of these 47 cases occurred in different spatiality. Using logistic regression found out that concurrent intake of warfarin and aspirin didn’t increase the probability of gastrointestinal bleeding. However, the distribution of specialty of warfarin prescribing period would significant affects the rate of bleeding.
|
|---|
