Preparation and release studies of alfuzosin matrix and matrix-coating system

• Main Authors: Wei-Yang Lee, 李維揚
• Other Authors: Kuo-Sheng Liu
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/3mhp48

碩士 === 嘉南藥理科技大學 === 藥物科技研究所 === 97 === Three common oral controlled delivery systems including matrix, reservoir, and osmotic pump system are often used in the pharmaceutical field. The aim of this study is to investigate the performance and mechanism of different formulations of alfuzosin hydrochloride using matrix and matrix-coating system. Different excipients such as water swellable polymeric matrices have found broad application in controlled release system, and diffusion often controls the rate of drug release from the system. Therefore, in order to control drug release, characterization of the effects of the polymer blends and polymer swelling on drug release diffusion is crucial. In the present study, direct compression method was utilized to prepare matrix tablets. The amounts of hydroxyl propyl methyl cellulose (HPMC) in matrix and various amount of hydrophilic / hydrophobic polymers in matrix -coating membrane were studied to assess drug release characteristics. The coating membrane used were percentage of 3% and 5%. Drug permeability and mechanical properties of polymer membrane with different composition were determined. Dissolution tests were performed according to the USP paddle method (900 ml medium, 37 ± 0.5℃ and 100 rpm). For matrix tablets, the results indicate that drug release rates can be decreased by increasing amount of HPMC. Swelling results are also consistent with drug release results. Higher swelling and less erosion were observed for tablet with higher amount of HPMC. For matrix-coating systems, the results indicate that drug release rates can be decreased by increasing amount of hydrophobic polymers in polymer blend and coating percentage. The results demonstrate that controlled release of alfuzosin hydrochloride is feasible using matrix and matrix-coating system.