Evaluation of nature material M as a disintegrant

• Main Authors: Hung-Chang Wu, 吳鴻璋
• Other Authors: Chun-Ren Chen
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/83h8ty

碩士 === 嘉南藥理科技大學 === 藥物科技研究所 === 97 === Fast dissolving dosage forms are drug delivery systems that dissolve or disintegrate in the patient’s mouth in less than a minute without the need for water. The objective of this study was to find some new materials as disintegrants. These new disintegrants improve tablet disintegration and dissolution when added in small amounts to tablet formulations. The efficiency of new disintegrants in promoting tablet disintegration and dissolution can overtake starch, was used as a disintegrant in orally tablets. The dissolution rate of the model drug, hydrochlorothiazide, was found highly dependent on both tablet disintegration efficiency and the solubility of base material(s) in the testing medium. In the end, we showed the effect of new disintegrants in promoting tablet disintegration and dissolution in pH1.2 HCl buffer.