The association of interleukin-1βpolymorphism and acute myocardial infarction
碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 97 === Heart disease was ranked on fourth among ten leading causes of death in 1999 in Taiwan. The significance of elevated serum cholesterol levels，and cigarette smoking as risk factors for the development of coronary heart disease has been well documented in nume...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2009
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| Online Access: | http://ndltd.ncl.edu.tw/handle/08564064002856964697 |
| Summary: | 碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 97 === Heart disease was ranked on fourth among ten leading causes of death in 1999 in Taiwan. The significance of elevated serum cholesterol levels，and cigarette smoking as risk factors for the development of coronary heart disease has been well documented in numerous studies. Neointimal hyperplasia， mainly the proliferation of smooth muscle cells and accumulation of macrophage-derived foam cells and interleukin-1β might play a central role in the process of atherosclerosis. Among several etiological risk factor，hypertension，cardiac disease，diabetes and myocardial infarction。IL-1β (interleukin-1β) is a cytokine with anti- inflammatory and evidence suggests a potential role for IL-1β in atherosclerosis . For discriminating the association between The aim of this study was to examine whether polymorphism of the IL-1βgene is associated with the risk of AMI. Therefore，we performed a case-control study from 183 patients .The study population comprised of 49 AMI patients (AMI)，58 healthy individuals with AMI disease history (control ⅡA)，76 personnel don'' have any conventional cardiovascular disease risk factors (control ⅡB). IL-1β gene polymorphism was performed by analyzing AvoⅠ-digested DNA fragment obtained by polymerase chain reaction (PCR). An association of the IL-1βC/C genetype of control group ⅡA to the AMI onset was found (p=0.02)，but not in control group ⅡB (0.551)。In conclusions，our result suggest that IL-1β polymorphism was associated with acutr myocardial infarction among Taiwansecohot with convestional cardiovascular disease risk factors,
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