| Summary: | 碩士 === 中山醫學大學 === 生物醫學科學學系碩士班 === 97 === The esophagus cancer ranks the ninth in the ten greatest cancers in Taiwan, most patient would be established diagnosis until later period, poor condition after usually causing to prepare, the diagnosis esophagus cancer in earlier period is important. Cervical cancer, ovary cancer rank in the ten greatest cancer of female, but endometriosis、adenometriosis and myoma always occur in female .So diagnose in early and the index sign after preparing has great significance. In early the method of SEREX to detect that the antibody of the cancer serum can recognize the tumor associated antigen(TAA), the most tumors related antigen caused because of cancer mutation, therefore detect these TAA from the autoantibody can become mark when the tumor become . The eight tumor associated antigens:IMP1,p 53, Cyclin B1, Ras, Csk, Erbb2, p90 and p16, detect the autoantibody of 66 general females and 38 general males with ELISA and the positive, The result finds that the same TAA to autoantibody is is different on the sex, among the p16 no matter males and females its autoantibodyall is high.Choose the general male positive rate lower p53(10.5%) and detect the autoantobody of esophagus cancer of 126 males patient, and calculate the positive . The result suggests that the patient''s positive rate is up to 26%, in other words p53 probably be the tumor marker in esophagus cancer.But the general male is too few to be enough to stand for great male, so enlarge to 70 .The result that the general down to 18%, the patient rise to 21%, so p53 can`t be used as tumor marker in esophagus cancer. Another,choosing the IMP1 and Cyclin B1 and detect the autoantibody of 56 gynecological patient and calculate the positive. The result suggest that IMP1 positive rate 14.29%, so IMP1 a can be used as tumor marker in gynecological disease .
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