Effects of Melon Pear on STZ-induced Type 1 Diabetic Mice

• Main Authors: Yu-Ru, 郭育儒
• Other Authors: 徐成金
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/35496562477502077726

碩士 === 中山醫學大學 === 營養學研究所 === 97 === Diabetes mellitus is one of the most common chronic diseases in the world. Moreover, its complications including retinopathy, nephropathy and neuropathy threaten the life of many patients. Pepino Melon pear (Solanum muricatum Ait) is a popular plant food in Penghu Island (Taiwan). The residences in Penghu area usually consider it as an anti-hypertensive and anti-diabetic food. In order to ensure the contribution of this fruit toward diabetes prevention and/or therapy, this research project is designed; and the influence of this food upon blood glucose, anti-oxidation systems and polyol pathway in diabetic mice was examined. In the first experiment, Pepino Melon pear at 10 and 20 % were added into diet of mice before diabetes was induced. In the second experiment, Pepino Melon pear was fed for mice after diabetes was induced. Results showed that Pepino Melon pear decreased blood glucose and serum’s oxidative damage, attenuated the activation of aldose reductase in diabetic mice group. These findings support that the Pepino Melon pear may delay the development of diabetic complications via alleviating oxidative stress and suppressing polyol pathway.