Study of modified Si Wu Tang on antioxidation andphysiological effect on liver and skin

• Main Authors: Ying- Hua, 吳英華
• Other Authors: 王進崑
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/81495249284814828352

碩士 === 中山醫學大學 === 營養學研究所 === 97 === Abstract Si Wu Tang is one traditional Chinese medicine, Si Wu Tang is an old formula containing four herbs, radix Angelicae sinensis (Dang Guay) , rhizoma Ligustici chuanxiong (Tsuan Chyong), radix Paeoniae alba (Bai Sau ), and radix Rehmanniae praeparata (Soe Dee Huang), It has been widely used to relieve menstrual discomfort in Taiwan. Si Wu contains a lot of organic acids、amino acids、polysaccharides、 vitamins、minerals and phenolic compounds .Many animal studies indicate that Si Wu Tang has antioxidation and anti-aging effect. This study was modified Si Wu Tang on anti-oxidation and physiological effect on liver and skin, including anti-oxidation ability of plasma, erythrocyte enzyme activities, liver function protection and the improvement on skin condition. This was a randomized, placebo controlled, double blind and cross over design.55 subjects (10 males and 45 females)were completed involved in this study. The total experimental period was thirteen months. One group of subjects took placebo in the first six months and Si Wu Tang in the next six months, one month between this two periods was wash out period. The other group of subjects took Si Wu Tang in the first six months and placebo in the next six months. Anthropometric measure-ements and blood collection were performed at the initial,3rd,6th,10th,13th month of the testing period. Abdominal ultrasound and skin examination were performed at the initial,6th,13th months. Each subject drank 120mL Si Wu Tang (11.71g polysaccharides, 0.5g flavonoid compounds and 68.4mg phenolic compounds) everyday for six days per month.Results showed that six months continuous administration of Si Wu Tang significantly increased total antioxidant capacity and reduced TBARS contents in plasma. The antioxidant enzyme activity of superoxide dismutase(SOD), catalase and glutathione reductase (GSH Rd) in erythrocytes was also increased. In addition,the abdominal ultrasound examination showed improvement on fatty liver, gall stone and mild splenomegaly. Increasing skin erythema, decreasing skin surface water loss and reducing skin wrinkles were found by the administration of Si Wu Tang.