| Summary: | 博士 === 中山醫學大學 === 醫學研究所 === 97 === Hyperventilation syndrome is defined as the condition of increased alveolar air exchange which leads to an excess exhalation of carbon dioxide and induces hypocapnia. Carbonic anhydrase (CA) play an important role in the hydration of carbon dioxide (CO2) to bicarbonate (HCO ). No article has been published about the relationship of CAs activity and hyperventilation syndrome. This study was to evaluate the erythrocyte carbonic anhydrases (CAs) activity in patients with hyperventilation syndrome and to compare with controls. Of seventy-one qualified cases and sixty controls were recruited in this study. We found that there were significant differences between cases and controls in erythrocyte total CA activity, the number of RBC, hemoglobin (Hb), hematocrit (HCT), and partial pressure of carbon dioxide (PaCO2). Moreover, a significant negative correlation was found between total CA activity and PaCO2 (r=-0.185, p=0.035). In conclusion, erythrocyte total CA activity concentration was elevated in patients with hyperventilation syndrome and it is a potential explanatory parameter for the clinical prediction.
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