| Summary: | 碩士 === 國立政治大學 === 科技管理研究所 === 97 === Most of previous the studies on pharmaceutical industry have been focused on the development strategy, environmental analysis and intellectual property. Very few of them emphasize the stage of new drug development concerning the project team management.
This study uses technological knowledge characteristics (path dependence, complexity, and explicitness) and drug development process (drug discovery, non-clinical, pre-clinical, and clinical ) to explore the effect upon project team management.
The result of this study：
1. In every stage of new drug development, the path dependence and the complexity of technological knowledge have significantly negative correlation.
2. When the new drug development project evolves into the clinical stage, the structure of project team will be different.
3. The complexity of technological knowledge can affect the composition of team members. If the complexity of technological knowledge is higher, the complexity of members is higher.
4. The path dependence of technological knowledge can affect the development strategy. If the path dependence is higher or lower, the team members prefer “inner development”. If the path dependence is medium degree, the team members prefer “primary inner development” and then “cooperative research and development”.
5. The path dependence of technological knowledge can affect the team structure. If the path dependence is higher, the enterprise prefers “Heavyweight team structure” or “Autonomous team structure”. If the path dependence is lower, the enterprise prefers “Lightweight team structure” or “Functional team structure”.
6. If the explicitness of technological knowledge is higher, the enterprise intends to recruit team member from outside.
7. In clinical stage, the practice investigator can be key person of the success.
8. If the enterprise has the ability of “primary inner development”, the time and the cost of the new drug development can be reduced.
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