Drug Release Behavior of Hydrogel Membrane composites based on Poly(vinyl alcohol)/Poly(acrylic acid)

• Main Authors: Chi-Ming Chan, 詹騏銘
• Other Authors: Kuan-Jiuh Lin
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/42751356636719015162

碩士 === 國立中興大學 === 化學系所 === 97 === Smart hydrogel, the semi-interpenetration polymer network system (semi-IPNs) composed of pH-sensitive polyacrylic acid (PAA) trapped with polyvinyl alcohol (PVA) in the present of glutaraldehyde (GA) as the cross-linker, is prepared for application in drug delivery of Acetaminophen. The structure and properties of as-produced hydrogels were investigated by Fourier transform infrared (FT-IR) analysis, Differential Scanning Calorimetry (DSC), X-ray diffraction pattern (XRD). Swelling rate of PVA hydrogels is inversely proportional to the cross-linker density, indicating the drug release rate from such hydrogels is determined by a density of the net and is lowered by a increase in the PVA : GA mass ratio. The swelling behaviors of PVA/PAA hydrogels and drug release from the hydrogels in relation to pH were investigated. As in neutral environment, the swelling velocity was much improved by introducing PAA in comparison with non-PAA, which is due to the enhancement of the entanglement of this hydrogel network resulted from electrostatic repulsive interaction of carboxylic (COO-) group. It indicated that the PAA introduced hydrogel system provided a suitable release profile for drug delivery vehicle.