Combined Toxicity of Reactive and Polar

• Main Authors: Chen, Xin-Yu, 陳欣妤
• Other Authors: Chen, Chung-Yuan
• Format: Others
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/17355567022465273023

碩士 === 國立交通大學 === 環境工程系所 === 97 === The joint action of reactive aldehydes and polar narcosis chlorophenols was analyzed using the Microtox test. The experimental results were compared with the predictive model. The results of this research agree with the non-interactive combined toxicity theory. The majority of synergistic joint actions observed were related to reactive toxicants having different mechanisms of toxicity and flat concentration-response curves. There was three interactive multiple toxicity cases：2-CP + propionaldehyde, 2,3-DP+ propionaldehyde, and the 4-CP+butyraldehyde. The complex joint action could be found between the propionaldehyde and the chlorophenol, indicated that interactive action happened. To study the chemical interactions, here uses the HPLC for analyze. Many toxicologists thought that concentration addition (CA) had a higher predictive power than independent action (IA). But they just ignored the condition of ρ= -1. In this study, we find that if the slope parameter is lower than 2, the IA model predicts a higher effect than CA. On the contrary, if the chemical has the sharp concentration-response curve, CA is more conservative than IA.