A Study Towards the Synthesis of Colchicine Derivatives
碩士 === 國立東華大學 === 化學系 === 97 === Colchicine is useful in suppressing the inflammation in acute gouty arthritis. It also can damage the bone marrow causing severe anemia and low white blood counts when patients receiving long-term therapy. Reducing white blood cell counts can increase the risk of inf...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2009
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| Online Access: | http://ndltd.ncl.edu.tw/handle/32921809180628600138 |
| Summary: | 碩士 === 國立東華大學 === 化學系 === 97 === Colchicine is useful in suppressing the inflammation in acute gouty arthritis. It also can damage the bone marrow causing severe anemia and low white blood counts when patients receiving long-term therapy. Reducing white blood cell counts can increase the risk of infections.
This thesis describes the synthesis of colchicine derivatives from the advanced intermediate A1 by Morita-Baylis-Hillman reaction. To synthesize the derivative in the hope that can increasing the effect on gout and reducing the severe side effects.
The finding of a method to synthesize bromo-derivative A2 which can easily be displaced by nucleophiles, and facilitate the preparation of derivatives for the future.
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