| Summary: | 碩士 === 國立高雄第一科技大學 === 環境與安全衛生工程所 === 97 === After a fire starts, heat, smoke and toxic gases are released and may hurt human beings. Previous studies usually focus on immediate effect of irritant and asphyxiant gases. The first part of this study evaluates the effect of combustion gases on human fertility. In addition, the FED（Fractional effective dose）model has been used to assess the risk of toxic harm by applying the LC50 （Lethal concentration 50%）. The value of the LC50 was measured with temperature of 25℃. If the temperature changes, is the FED model still reasonable？
In the first part of this study used the test method of hazardous fumes （CNS 8738）in which mouse can expose to combustion gases. In long exposure tests, the mice expose to the combustion gases for 4 and 8 minutes twice a day for 13 weeks and in short exposure tests, the mice expose until two of eighteen mice die. In the second part of this study, mice were arranged in an enclosure to expose to carbon monoxide with different concentrations（0, 2000, 4000, 6000 and 8000 ppm）and temperatures（20, 30 and 40℃）.
The data shows the combustion gases have effect on the sperm chromatin structure assay（SCSA）and mitochondrial membrane potential（MMP） after the long exposure while only the mitochondrial membrane potential（MMP）was influenced after the short exposure. Significantly, the toxic gases result in harm of fertility. In addition, the temperature rise strongly increases the number of mice which die during the exposure. The value of the LC50 is different while the temperature changes.
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