The study of associations between PCDD/Fs, PCBs, OCPs and PBDEs in breast milk and thyroid, growth, and steroid sex hormones

• Main Authors: Ding Yan Lin, 林鼎彥
• Other Authors: How Ran Chao
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/72021560198874853565

碩士 === 國立屏東科技大學 === 環境工程與科學系所 === 97 === Polychlorinated dibenzo-p-dioxins (PCDDs, dioxins), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and polybrominated diphenyl ethers (PBDEs) are environmental endocrine disruptors that have half-lives of 18 days–12 years in the human body and have toxicities that probably include carcinogenesis. In this cohort study of maternal samples, we examined the relationship of PCDD/PCDFs, PCBs, OCPs, and PBDEs exposure to levels of thyroid, growth, and steroid sex hormones in the sera and cord blood of 42 pregnant women 25–34 years of age from central Taiwan. Maternal blood was collected during the third trimester, and the cord blood was collected at delivery. We measured 16 dioxin congeners, 12 dioxin-like PCBs, 7 OCPs, and 12 PBDEs in breast milk using gas chromatography coupled with high-resolution mass spectrometry. Hormones in maternal serum and cord blood were analyzed by liquid chromatography tandem mass spectrometry. With spearman’s rank correlation, Factors analysis,and multiple stepwise linear regression, before factors analysis, the study found the concentrations of mTransthyretin increased with increasing exposure to 2,3,3',4,4',5'-HxCB (157) (β = 0.011, p = 0.014 by the stepwise linear regression model). The concentrations of cT3 increased with increasing exposure to Total PCDDs TEQ (β = 3.48, p = 0.007 by the stepwise linear regression model). The concentrations of cT3U decreased with increasing exposure to 1,2,3,4,7,8-Hexa-CDD (β = -0.406, p = 0.004 by the stepwise linear regression model). Meanwhile, after factors analysis, the concentrations of cCORTISOL decreased with increasing exposure to Heptachlor epoxide+DDE+DDT (β = -4.22, p = 0.046 by the stepwise linear regression model). The concentrations of cIGF1 decreased with increasing exposure to DDE+Total non-ortho PCBs (β = -20.3, p = 0.026 by the stepwise linear regression model). For the statistical competition with PCDD/PCDFs, PCBs, OCPs, this study hopes it can gives people some ideas in future.