Multiple testing procedures based on the difference of restricted mean lifetimes for right-censored survival data

• Main Authors: B.C.Shen, 沈炳辰
• Other Authors: Y.M.Chan
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/12311907009368870782

碩士 === 東海大學 === 統計學系 === 97 === In clinical trials and drug development studies, we are often interested in identifying which treatment or dose level is more effective than the control or zero dose group in prolonging the survival time of patients. In this thesis, we consider the closed step-down testing procedures and generalized Steel’s test based on the differences of the restricted mean lifetimes between each treatment and control groups for right-censored survival data. We further conduct a simulation study to investigate the relative error rate and power performances of the competing procedures under different hazard alternatives, restricted time points and samples sizes. Finally, the use of those procedures is illustrated with two right-censored survival data sets.