Albumin administration in patients with severe sepsis due secondary peritonitis

• Main Authors: Chih-Dou Chou, 周志道
• Other Authors: Cheng-Deng Kuo
• Format: Others
• Language: en_US
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/b2t664

碩士 === 國立陽明大學 === 急重症醫學研究所 === 97 === Background: To determine whether intravenous administration of human albumin can reduce the mortality in patients with severe sepsis due to secondary peritonitis. Methods: Adult patients who were admitted to the surgical intensive care unit (SICU) fulfilled the criteria of severe sepsis due to secondary peritonitis were consecutively included in this study retrospectively. Patients who received and did not receive at least daily minimal 25 g intravenous human albumin for 3 days during their first 7 days of SICU admission were classified as study group and control group, respectively. Results: One-hundred and thirty-three patients were included in this study. For patients with baseline serum albumin of 20 g/l or less, the 28-day mortality was significantly lower in the study groups. For patients with baseline serum albumin greater than 20 g/l, albumin administration has no significant effects on 28-day mortality . Conclusions: For patients with severe sepsis due to secondary peritonitis, albumin administration may reduce the 28-day mortality in patients whose baseline serum albumin was 20 g/l or less; but no such effect was found in patients whose baseline serum albumin was greater than 20 g/l.