Inhibition of U87MG cell growth by carmustine and doxorubicin entrapped catanionic solid lipid nanoparticles

• Main Authors: cheng-te liang, 梁正德
• Other Authors: none
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/91358404686583160778

碩士 === 國立中正大學 === 化學工程所 === 98 === The anticancer drugs, carmustine (BCNU) and doxorubicin (Dox), entrapped by solid lipid nanoparticles (SLNs) were used in this study. SLN lipid matrix was composed of cacao butter (CB), stearic acid (SA). SLN liquid phase contained equal molar ratio of hexadecyltrimethylammonium bromide (HTMAB) and sodium dodecyl sulphate (SDS) to form catanionic surfactant mixture. The smallest nanopaticle diameter was abtained at 1 mM catanionic surfactant. The maximum entrapment efficiency of BCNU-SLN was 81%, Dox-SLN was 61%. Moreover, XPS analysis data was shown that equal molar ratio of nitrogen and sulfur element on SLN surface. Furthermore, cell growth inhibition of glioblastma U87MG by BCNU-SLN and Dox-SLN results the decrease of epidermal growth factor receptor expression while time increased. We considered that U87MG was inhibited by drug carrier.