| Summary: | 碩士 === 國立中正大學 === 生命科學系暨分子生物研究所暨生物醫學研究所 === 98 === Background and objectives: Taiwan has the highest incidence and prevalence of end-stage renal disease (ESRD) worldwide. Haptoglobin (Hp) has a role in renal protection, and there are known differences in the function and geographic distribution of different Hp alleles. We studied the association between Hp genotype and chronic kidney disease (CKD) in Taiwan.
Design, setting, participants, & measurements: There were 401 study subjects, 205 CKD patients and 196 healthy controls. The three major Hp genotypes were determined by the polymerase chain reaction and electrophoresis. Multiple logistic regression was used to identify risk factors associated with CKD, and trend tests were used to identify genotypes associated with advanced CKD.
Results: Subjects with CKD were older and more likely to have diabetes, hypertension, elevated uric acid and reduced hematocrit. There were no differences in the distribution of Hp genotypes and allele frequency between CKD patients and controls. The Hp2-2 genotype was associated independently and negatively with advanced CKD (OR, 0.487; 95% CI, 0.248-0.957; p = 0.037). Conversely, anemia was associated independently and positively with advanced CKD (OR, 9.208; 95% CI, 4.151-20.428; p < 0.001). The Hp genotype was significantly associated with CKD severity (p = 0.023). A higher percentage of Hp1-1 patients had advanced CKD, and a higher percentage of Hp2-2 patients had mild CKD.
Conclusions: This study found no evidence that Hp genotype affects the development of CKD. However, Hp genotype is significantly associated with CKD severity. The Hp1-1 genotype is an independent risk factor for advanced CKD. We suggest that future studies examine the potential use of Hp genotype as a prognostic indicator for the development of advanced CKD.
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