Long-term Low-dose Fructose-Induced RenalInjuries in the Mouse

• Main Authors: Ya-Hui, 鄭雅惠
• Other Authors: Han-Hsin Chang
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/67524146094204309723

碩士 === 中山醫學大學 === 營養學研究所 === 98 === Fructose intake has been associated with increased prevalence of metabolic syndrome a trend, and in the epidemiology of metabolic syndrome and the development of renal injury in very relevant.It is hypothesized that different metabolic pathways of fructose,in mice may lead to different physiological and morphological response to changes in kidney level. The purpose of this study was to explore the drinking water of 20% fructose-induced animal model of chronic renal damage.using Hematoxylin & eosin staining of renal biopsy is caused by chronic injury, and to explore the fructose for the Morphology of renal pathology in mice and quantitative analysis. The results showed that diet containing 20% fructose involved in histopathological patterns found that fructose can cause kidney significantly reduce the number of Martin''s capsule (P <0.01), and renal vascular and Martin''s capsule basement membrane thickening trend Powell also showed a visible capsule case of accumulation of red blood cells (P <0.01). It can be seen，this study found that 20% of fructose fed mice may induce the occurrence of chronic renal injury, while fructose-induced kidney disorders and metabolic syndrome. Therefore, the consumption of fructose diet and chronic renal injury in development will be more worthy of attention.