| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 98 === The aim of this study was to investigate the anti-diabetic effect of Leave essential oil of Cinnamomum osmophloeum Kaneh. Male Wistar rats were induced to be diabetes with STZ (65 mg / kg BW, iv). At three days after the induction of diabetes, rats received every other day for 8 times by gavage low, medium or high dose of leave essential oil of Cinnamomum osmophloeum Kaneh. , Cinnamaldehyde (40mg/kg Bw), glybenclamide（1.2 mg/kg Bw) or vehicle (corn oil, 2 ml/kg Bw). Control rats received corn oil only. ITT or OGTT was carried out at 10 or 17 days after the induction of DM, respectively. At 21 days after the induction of DM, rats were killed with CO2 after overnight starvation, followed by the collection of biological samples from rats. It showed that leave essential oil of Cinnamomum osmophloeum Kaneh. improved the metabolic status and muscle loss, ameliorated fasting blood sugar, lowered blood fructosamine concentration, and elevated both fasting plasma insulin and pancreas insulin levels in diabetic rats. These effects are comparable to that of oral hypoglycemic agents. Leave essential oil of Cinnamomum osmophloeum Kaneh. also significantly improved oral glucose tolerance and the increment of plasma levels of insulin, GLP-1, and GIP during OGTT period. In the other hand, data from ITT and the calculated values of HOMA-IR showed that the hypoglycemic effect of leave essential oil of Cinnamomum osmophloeum Kaneh. was partly due to ameliorated insulin sensitivity. The reduced peripheral level of free fatty acids by the tested essential oil suggested its indirect beneficial effect on insulin sensitivity. In addition, leave essential oil of Cinnamomum osmophloeum Kaneh. reversed renal hypertrophy in diabetic rats and reduced peripheral uric acid concentration in diabetic rats. The results of the present study suggest that leave essential oil of Cinnamomum
osmophloeum Kaneh. possesses anti-diabetic effect and such effect is at
least partly performed by cinnamaldehyde in this preparation.
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