| Summary: | 博士 === 中山醫學大學 === 醫學研究所 === 98 === Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. The aim of this study was to examine the potential associations of two hypoxia inducible factor-1α (HIF-1α) gene polymorphisms, C1772T and G1790A, with the susceptibility and clinicopathological status of hepatocellular carcinoma. A total of 449 subjects, including 347 healthy controls and 102 patients with hepatocellular carcinoma, were recruited in this study and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses to estimate the impact of these two polymorphic variants on hepatocellular carcinoma. G1790A heterozygotes showed a higher risk for hepatocellular carcinoma, compared to GG genotypes after adjusting for other confounders (AOR=3.97; 95%CI=1.70-9.22), indicating a significant association between hepatocellular carcinoma susceptibility and G1790A polymorphism. Moreover, results also revealed the presence of synergistic effect between gene polymorphism of HIF-1α G1790A and environmental risk factors, such as tobacco and alcohol consumptions while there was no significant association between HIF-1α gene polymorphism and clinicopathological parameters of hepatocellular carcinoma. In conclusions, genetic polymorphism at G1790A of HIF-1α is an important factor for determining the susceptibility to hepatocellular carcinoma. The interaction effects of G1790A heterozygotes to tobacco and to alcohol consumption significantly increase the risk to develop hepatocellular carcinoma.
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