| Summary: | 碩士 === 中山醫學大學 === 免疫學研究所 === 98 === OBJECTIVE:
Celiac disease(CD) is a inflammatory enteropathy induced by gliadin in genetically susceptible individuals. Recent report showed link between CD and other autoimmune disease .The relationship between anti-gliadin antibody and patients with autoimmune disease were estimated in the study.
METHODS:
The antigen of gliadin were tested in patients with autoimmune disease by enzyme-linked immusorbent assay(ELISA).The sera sample were consisted of 126 patients with Sjogren’s syndrome(SS),and 84 patients with Systemic lupus erythematosus(SLE),42 patients with Rheumatoid arthritis,42 patients with Diabetes mellitus , 42 patients with Ankylosing spondylitis , 42 patients with Hepatitis C virus and35 patients with Anemia. The 27 serum of health group were also obtained.
Results:
In analysis of anti-gliadin IgA antibody,12(9.52%)of 126 patient serums with SS,21(25%)of 84 patient serums with SLE,1(2.38%) of 42 patient serums with RA,6(14.3%)of42patient serums withDM,3(8.57%)of 35 patient serums with Anemia, 3(7.1%)of42patient serums with AS, 9(21.43%)of42patient serums with HCV, 1(3.7%) of 27 the health group have antibody reacted with gliadin.
Conclusions:
Our result shows that the patients with SLE were higher anti-gliadin antibody than patients with other autoimmune disease.
The relationship between the patient s with CD and other autoimmune disease should be estimated in the future.
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