Addition of yttria-stablized zirconia improves the biocompatibility of resin-modified glass-ionomer cement

• Main Authors: Wei-Ting, 林韋廷
• Other Authors: Yuh-Yih Lin
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/36152360296511724516

碩士 === 中山醫學大學 === 口腔生物暨材料科學研究所 === 98 === Resin-modified glass-ionomer cements (RM-GICs) containing a basic ion-leachable glass, a water soluble polymeric acid, organic monomer and an initiator system, was considered not as biocompatible as conventional GICs. This study, therefore, was focused on the effects, especially adverse cellular reactions, of yttria-stabilized zirconia (YSZ) addition on resin-modified GIC. YSZ powder was added into Fuji II LC (GC, Japan) in the ratios of 0%, 5%, 10%, and 20%, respectively, molded into columns (2 mm x 4 mm), and light-cured as instructed. There were no statistically significant differences between groups in their compressive strength and diametric tensile strengths, although the group of 20% YSZ addition showed slight reductions. When incubating L929 cells, a fibroblast cell line, with cured 0-3day RMGIC-YSZ eluates, YSZ addition showed a dose dependent improvement of cell vitality, with a 25% increase in 10% YSZ group compared with the control（p＜0.05）. Better cell attachment was observed under electronic microscope in the YSZ group than the control. The production of COX-2 by L929 cells when incubating with RM-GIC eluates, was curbed by the addition of YSZ, also in a dose-dependent pattern, but there were no statistically significant differences between groups in TNFα production . We concluded that the addition of YSZ is capable of improving biocompatibility of GIC without compromising mechanical strength.