The morphology and particale sizes of microemulsions fabricated and controlled by a novel microfluidic device

• Main Authors: Lin, Zi-jun, 林子鈞
• Other Authors: 葉安祺
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/95663179105490231316

碩士 === 正修科技大學 === 化工與材料工程研究所 === 98 === In this thesis, we designed a simple microfluidic device by using of micropipette tips being joined coaxially of injection tube, transition tube and the glass of square capillary. This device is less complicated in comparison with Micro-electro-mechanical (MEMS)/Soft-lithography technique. The microfluidic includes 1% alginate and Sunflower oil and 60,65,70% Glycerol +0.2M CaCl2 solution being in injection tube, transition tube and colletion tube respectively to generate monodisperse emulsions, double emulsions as well as be applicable for triple emulsions formation. The diameter of single emulsion is between 65 and 250 μm. The inner diameter of double emulsion is about 270 to 370 μm and the outer diameter is 880 μm ~ 1.08 mm. Meanwhile, the number of inner droplets can precisely be controlled by adjusting the flow rates. The inner diameter of triple emulsion is about 238 ~ 273μm, middle diameter is 557 ~ 600 μm and outer diameter is 1.3 ~ 1.5 mm. The number of the three double emulsions is capsulated in inner of the triple emulsion. In the single emulsion, droplets are formed in the transition tube, when the flow rate in injection tube Qi is 25、50、100 μL/min respectively, the flow rate in collection tube Qc is fixed(ex.300 μL/min) and the flow rate in transition tube Qt is increased from 1500 to 3500 μL/min. When the rate of Qt is fixed, the pressure drop for droplet being created is increased when the Qi is increased. Additionally, the droplet size of the radius is increased also. If the rates of Qt increases, the pressure drop decreases when the Qi is increased and the droplet size of the radius is decreased as well. In the double emulsion, droplets are formed in the collection tube. When Qi and Qt are fixed (100 μL/min, 2000 μL/min, respectively), Qc is increased from 2000 to 5000 μL/min and the droplet being created pressure drop is decreased and the droplet size of the radius is decreased as well. Furthermore, in the other conditions of the double emulsion, droplets can be formed in the transition tube if Qt and Qc are fixed at 1000 μL/min and 3500 μL/min respectively. When the rate of Qi is increased from 25 to 250 μL/min, the droplet being created pressure drop is increased, the droplet size of the radius is increased. If the rate of Qi is fixed, the droplet created pressure drop and droplet size of the radius has no change at all. Since Microemulsion technology has been widely used in drug delivery, biomedical engineering, cosmetics, food industry and other commercial industries, our research results can be used for a lot of important applications.