Chemical Constituents and Biological Activities of Cinnamomum reticulatum Hayata

• Main Authors: Hung-Chun Yeh, 葉宏淳
• Other Authors: Chung-Yi Chen
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/53526053757679072386

碩士 === 輔英科技大學 === 醫事技術系碩士班 === 98 === Cinnamomum reticulatum Hayata （Lauraceae） is an evergreen trees, an arbor indigenous to Taiwan. We have collected the methanolic extracts of the leaves and stems of C. reticulatum Hayata for evaluation of their in vitro antiproliferative effects and antioxidant capacity. Therefore, we investigated the chemical constituent of the leaves and stems of C. reticulatem. Totally 12 compounds including two sesquiterpenoids：tenuifolin (1) and reticuol (2); one normonoterpenoid: reticuone (3); one steroid ： β-sitostenone (4); one benzenoid ： p-hydroxybenzoic acid (5); one monoterpene ： 2,6-dimethyl-1,7- octadiene-3,6-diol (6); one lignan：isoanwulignan (7); one quinone: α-tocopheryl quinone (8); two flavonoids：kaempferol-3-O-(2″,4″-di-E- p-coumaroyl)-α-L-rhamnopyranoside (9) and kaempferol-3-O-(3″,4″- di-E-p-coumaroyl)-α-L-rhamnopyranoside (10); two chlorophylls ： pheophorbide a (11) and aristophyll C (12). Among them, tenuifolin (1), reticuol (2) and reticuone (3) are new compounds. On antiproliferative effects, 10 showed inhibition of A549、 NCI-H460、MCF-7 and MDA-MB231. On antioxidant capacity, 9 showed scavenging effect of DPPH, and 9 and 10 effect of reducing power.