| Summary: | 碩士 === 弘光科技大學 === 職業安全與防災研究所 === 98 === Abstract
Occupational exposure to foundry dust, silica particles, metals and polycyclic aromatic hydrocarbons (PAHs) has been reported in foundry industries. The previous study interpreted that foundry workers have a higher risk of exposure to metals emitted during the operating process in a foundry. In addition, PAHs are also considered as a serious problem in foundry plants due to the high temperature and un-completed combustion. Therefore, PAHs were considered as a cause to result to oxidative DNA damage, and the hazards exposure might trigger some adverse health problems in foundry’s workers. Therefore, we aimed to evaluate the oxidative damage of foundry workers with different job tasks and the association between 1-OHP, metal exposure and oxidative damage in foundry workers.
Significantly higher 1-OHP levels(0.32μg/g creatinine vs 0.17μg/g creatinine) (p＝0.01), malondialdehyde (MDA) levels (4.28 µM vs 1.64 µM) (p<0.0001), DNA strand breakage (6.63 vs 1.22) (p<0.0001) and 8-hydroxydeoxyguanosine (8-OH-dG) levels (5.00 µg/g creatinine vs 1.84 µg/g creatinine) (p=0.001) were found in exposure group compared with the control group. Higher levels of these parameters were also found in workers involved in manufacturing than in workers involved in administration. A positive correlation was identified between levels of 1-OHP and 8-OH-dG, DNA strand breakage and MDA in all study subjects. However, the workers may be exposed to PAHs emitted from the furnace and pouring areas of a large foundry does not have well-separated working departments. Furnace type, melting temperature and casting conditions may also affect PAH exposure when working in different departments. DNA strand breakage can be interpreted to that the DNA damage reflected the short-term exposure, such as the air sampling. 8-OH-dG may cause more seriously oxidative damage by life style or other pollutions. MDA is a long working history and work in the foundries should be given seriously consideration in occupational disease prevention.
This study also suggested that co-exposure to metal and PAHs, and smoking status in foundry industries may also cause the oxidative damage in foundry workers. These results indicate health risk as high levels of oxidative damage may increase susceptibility to carcinogenesis and cancer.
|
|---|
