The investigation of the association ofangiographically defined coronary arterydisease and periodontal disease

• Main Authors: Tzu-Hsuan Yang, 楊子萱
• Other Authors: Kun-Yen Ho
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/95883085283924915745

碩士 === 高雄醫學大學 === 牙醫學研究所 === 98 === Abstract Objective: This study aims to evaluate the association between angiographically defined coronary artery disease and periodontal status clinically. Materials and methods: Patients with the history of coronary artery disease(CAD) and CAD syndromes were assessed with a thorough clinical evaluation by an experienced cardiologist. Coronary angiography was considered to identify coronary lesions and , if needed, to treat appropriately. The evaluation of periodontal condition was by full mouth special charting for the site of probing depth > 4mm, attachment level > 5mm, bleeding on probing and plaque index. Results: The samples were grouped as subjects with CAD (n=44) and without CAD (n=26). The percentage of probing depth > 4mm(p=0.0064, by student’s t-test), attachment level loss > 5 mm(p=0.0305) and plaque index(p=0.0492) are significantly higher in the CAD group. The severity of CAD and the severity of periodontal disease is significantly associated. After adjustment for other factors common to both diseases, the severity of CAD assessed by diffuse score and periodontal disease assessed by the percentage of attachment loss > 5 mm is statistically significant (β=0.04, p=0.0022), and the severity of CAD, hs-CRP and glycated hemoglobin were also significantly associated (β=0.04, p=0.0011, and β=0.53, p=0.0015, respectively). Conclusions: After accounting for factors common for both diseases, there is a significant association between periodontal disease and CAD assessed angiographically. Further investigations should focus on other inflammatory markers between periodontal disease and CAD. Key word: Coronary artery disease, diffuse score, periodontal disease.