| Summary: | 碩士 === 高雄醫學大學 === 醫學研究所 === 98 === Background:
Iron overload have been implicated in status of inflammation and cardiovascular events. Insulin plays critical roles in progression of diabetic complication. We cross sectionally examined relationships between serum ferritin and insulin sensitivity in type 2 diabetic patients in Taiwan.
Methods and materials:
We cross sectionally recruited 442 type 2 diabetes and insulin sensitivity was assessed as QUICKI (Quantitative insulin sensitivity check index).
Result:
Tertiles of ferritin were significantly associated with fasting plasma glucose, hemoglobin A1c, and QUICKI as well as insulin resistance as HOMA-IR. Tertiles of ferritin significantly and positively correlated with other metabolic syndrome related parameters including blood pressure, triglyceride, central obesity, HDL-C, fasting plasma glucose. Consumption of red meat and white meat were also significantly different among tertiles of ferritin groups. In multiple linear regression analysis adjusted for known risk factors ( including age, BMI, sex, blood pressure, HbA1c, duration of disease , smoking , drinking habit, TG, HDL-C, Creatinine and various dietary factors), ferritin tertiles correlated negatively with QUICKI at increment of -0.006 (beta=-0.006, p=0.006). In multiple logistic modeling, highest tertiles had about 1.9 fold (OR: 1.91, 95% CI: 1.06-3.44) decreasing insulin sensitivity compared to the lowest tertiles of ferritin.
In conclusion, increased ferritin levels may decrease insulin sensitivity in type 2 diabetes.
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