Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex
碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 98 === This research is focusing on developing the Gd ligands which have potential to targeting contrast agent. The carboxylic acid terminal of 5-(1-bromoacatamido)-2,3-dihydro-1-oxo-1H-indene-2-acetic acid can be modified with appropriate peptide or other target spe...
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ndltd-TW-098KMC055370012015-11-11T04:15:07Z http://ndltd.ncl.edu.tw/handle/03589625003821062214 Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex 配位子DOTA-OIA之合成及其釓金屬錯合物之物性及化性研究 Iok-Sun Lei 李毓璇 碩士 高雄醫學大學 醫藥暨應用化學研究所 98 This research is focusing on developing the Gd ligands which have potential to targeting contrast agent. The carboxylic acid terminal of 5-(1-bromoacatamido)-2,3-dihydro-1-oxo-1H-indene-2-acetic acid can be modified with appropriate peptide or other target specific residue to develop target specific MRI contrast agent for potential application in tumor imaging. This research is to develop a ligand which has the character of optimal lipophilicity. The calculated value obtained for [Gd(DOTA-OIA)] (miLogP = -4.147) is similar to that of MS-325 (-4.575) which is clinically used blood pool MRI contrast agent. Together with the help of 1H-NMR、and the identification of LC-MS. I have successfully synthesized 5-(1-bromoacatamido) -2,3- dihydro-1- oxo-1H-indene-2-acetic acid. With the result of identification of LC-MS, its molecule weight is 327.93 which meets the expectation value. The synthesis of [Gd(DOTA-OIA)] is still in progress and expected to complete soon. The synthesis of [Gd(DOTA-OIA)] will be completed and get the spectral of last step. By using 20MHz relaxometor to measure the relaxivity. Chai-Lin Hsu 許智能 2010 學位論文 ; thesis 98 zh-TW |
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碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 98 === This research is focusing on developing the Gd ligands which have potential to targeting contrast agent. The carboxylic acid terminal of 5-(1-bromoacatamido)-2,3-dihydro-1-oxo-1H-indene-2-acetic acid can be modified with appropriate peptide or other target specific residue to develop target specific MRI contrast agent for potential application in tumor imaging. This research is to develop a ligand which has the character of optimal lipophilicity. The calculated value obtained for [Gd(DOTA-OIA)] (miLogP = -4.147) is similar to that of MS-325 (-4.575) which is clinically used blood pool MRI contrast agent. Together with the help of 1H-NMR、and the identification of LC-MS. I have successfully synthesized 5-(1-bromoacatamido) -2,3- dihydro-1-
oxo-1H-indene-2-acetic acid. With the result of identification of LC-MS, its molecule weight is 327.93 which meets the expectation value. The synthesis of [Gd(DOTA-OIA)] is still in progress and expected to complete soon. The synthesis of [Gd(DOTA-OIA)] will be completed and get the spectral of last step. By using 20MHz relaxometor to measure the relaxivity.
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author2 |
Chai-Lin Hsu |
author_facet |
Chai-Lin Hsu Iok-Sun Lei 李毓璇 |
author |
Iok-Sun Lei 李毓璇 |
spellingShingle |
Iok-Sun Lei 李毓璇 Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex |
author_sort |
Iok-Sun Lei |
title |
Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex |
title_short |
Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex |
title_full |
Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex |
title_fullStr |
Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex |
title_full_unstemmed |
Synthesis of DOTA-OIA and Physicochemical Characterization of Its Gd(III) Complex |
title_sort |
synthesis of dota-oia and physicochemical characterization of its gd(iii) complex |
publishDate |
2010 |
url |
http://ndltd.ncl.edu.tw/handle/03589625003821062214 |
work_keys_str_mv |
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