A Simulation Study on Active Transport of Biomolecules in Axons Using the Michaelis-Menten Mechanism

• Main Authors: I-Ming Lin, 林義&;#29641;
• Other Authors: Hou-Chien Chang
• Format: Others
• Language: zh-TW
• Published: 99
• Online Access: http://ndltd.ncl.edu.tw/handle/15489035203756624393

碩士 === 國立中興大學 === 化學工程學系所 === 98 === Intracellular transport is an important mechanism to maintain neural function because of axonal specificity. For example, we found axonal swelling or the formation of spheroid in neurodegenerative diseases, and axonal transport is considered the important factor for neurodegenerative diseases. Axonal transport of biomass is divided into two in neuron. The former is that small molecules diffuse freely in the axon, such as the transport of ATP in cells. The latter is that cargo (organelles or viscles) associated with motor proteins. Motor proteins use the energy generated by ATP hydrolysis, and drag cargo along the cytoskeleton movement. It is called axonal transport, such as neurotransmitter, cytoskeletal polymers and so on. Mathematical model proposed by Smith and Simmons assumes that the velocity of particles is constant. Compared with the previous model, this study adds the continuity equation for species ATP to describe the distribution of ATP concentration, and uses Michaelis-Menten kinetics to derive the velocity of the motor protein. This study simulates distribution of the particles due to the inhibition of kinesin, inhibition of dynein and both. Results are compared with the literatures.