| Summary: | 碩士 === 國立臺灣海洋大學 === 生物科技研究所 === 98 === Biomaterial researches have been improved in past years. Mesoporous silica has stable structure, high surface area, size-controllable pores, functionalized surfaces, nontoxic and high biocompatibility. Mesoporous silicas also have some advantages in drug delivery system（DDS）,for example：the reappearance of the drug release curve, nontoxic after collapsed of the material, and not easily attacked by immune system.
Mesoporous bioactive glass development has been rising in recent years, it combined mesoporous silica and bioactive glass together. The combined material maintained high surface area characteristics and with its highly bioactive property, it can form hydroxyapatite in bone tissue. By collocation with functionalized surface and osteogenesis components, MBGs open the door of the designing of novel mesoporous materials to the special medicinal applications.
This project tries to modify the pore size by changing different synthesis temperature, and using 4-Acetamidophenol as a model drug to discuss the drug storage and release behavior of different pore size, and to study if they can be a proper carrier in DDS.
This thesis utilizes in situ hydrothermal to synthesize new lanthanide crystal [Ln(μ1-tzbc)(μ2-tzbc)(OH)(H2O)4]2（tzbc = Tetrazole benzylcarboxylate）, containing carboxyl functional group. The crystal system in this series of lanthanide compounds are monoclinic and space group P-1. For Gadolinium: a(Å)=8.3531(3),b(Å)=10.4026(4)，c (Å)=13.4249(3), α(°)=109.913(3),β(°)=101.288(2),γ(°)=101.114(3).This crystal is constructed by two lanthanide atoms as a structure center which linked four carboxyl functional group, two μ1 mode and two μ2 mode. In physical test we did element analysis, FT-IR, thermal gravimetric analysis, luminescent tests, and in bio-test we discussed the interaction between compound and double helix.
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