The Expression and Role of Inflammatory Cytokines in Oral Squamous Cell Carcinoma

• Main Authors: Yu-Hsin Chang, 張妤欣
• Other Authors: 賈景山
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/14339090795244812248

碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 98 === Inflammation is an important risk factor of carcinogenesis. The mechanism of inflammation leading to carcinogenesis is still unclear, but inflammatory chemokines or cytokines may play some roles to stimulate cancer cell proliferation or inhibit apoptosis. Inflammatory reactions may also release differnt reactive oxygen species leading to DNA damage. Chemokines and cytokines, particulary those associated with Th17, regulatory T cells and macrophages were related to cancer initiation and progression. But the expression level of these chemokines or cytokines and their relationship to the prognosis and clinicopathological status of oral cancer is still unknown. A total of 16 oral squamous cell carcinoma (OSCC) tissue and 4 non-cancer tissue were included in this study. The bacterial 16S ribosomal DNA was detected by PCR, and the expression level of cytokines and chemokines were quantitated by real-time PCR. The expression of il-1β　(p=0.018), tnf-α　(p=0.008), il-6　(p=0.018), tgf-β　(p=0.03), and ccl-7 (p=0.012) are higher in OSCC tissue whereas ccl-21　(p=0.023), foxp3　(p=0.038) and il-17　(p=0.028) are higher in non-cancer tissue. Proinflammatory cytokines and CCL-7 may recruit more inflammatory cells into cancer microenvironment and contribute to tumor progression. IL-17, which was highly expressed in non-cancer tissue, could play important role in control extracellular bacterial infection, and Foxp3, a Treg transqription factor may disminish the inflammatory response by their immunosuppression function.