| Summary: | 碩士 === 靜宜大學 === 食品營養研究所 === 98 === Hyperglycemia-induced oxidative damage plays an important role in the development of cardiovascular diseases in type 2 diabetic patients. The antioxidative, hypoglycemic, and hypolipidemic effects of green tea extract (GTE) rich in epigallocatechin gallate (EGCG) have been well-known. The purpose of this study was to investigate the effect of EGCG-rich GTE on thrombogenic risk in STZ-induced diabetic rats. Seventy-five male Wistar rats were randomly assigned into five experimental groups, including normal control(C), diabetic control(D), diabetic rats with 100mg/kg B.W./day of GTE (L), diabetic rats with 250mg/kg B.W./day of GTE (M), and diabetic rats with 500mg/kg B.W./day of GTE (H). After 8 weeks of feeding, concentration of fasting glucose, antioxidative markers (TAS、Catalase、SOD、GPx、MDA), inflammatory markers (CRP、IL-6、TNF-α), coagulation factor VII (FVII), anticoagulation factor (AT-III and Protein C), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) were measured. The results of this study showed that TAS was increased and MDA was decreased significantly (p<0.05) in diabetic rats fed with GTE. The concentration of fasting glucose was decreased and the activity of renal GPx was increased significantly (p<0.05) in diabetic rats with medium and high doses of GTE. When compared to diabetic control rats, the concentration of IL-6 was decreased significantly (p<0.05) in diabetic rats with high dose of GTE, however, CRP value was not affected by GTE feeding. Activity of factor VII, PAI-1 and concentration of vWF all tended to be decreased by GTE supplementation. In conclusion, supplementing EGCG-rich GTE may have beneficial effects to decrease oxidative stress, to ameliorate chronic inflammation and abnormal blood coagulation, and hence decrease the risk to develop thrombogenic complications in STZ-induced diabetic rats.
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