| Summary: | 碩士 === 臺北醫學大學 === 生藥學研究所 === 98 === Indomethacin is one of the commonly used non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis. However,gastric ulcer is a common side effect of this drug. The purpose of this study was to investigate the effect of combined administration of indomethacin with Ping-wei san (PWS), a commonly used traditional Chinese medicine for the treatment of gastrointestinal disease, on reducing the side effects of indomethacin without affecting its efficacy. Indomethacin (0.5 mM) was used to induce gastric mucosal cell injury and gastric ulcer. Co-administration of PWS (0.625 ~ 2.5 mg / ml) resulted in a dose-dependent inhibition of indomethacin-induced gastric mucosal cell toxicity. PWS (200 mg / kg) could also reduce the indomethacin (40 mg / kg)-induced gastric ulcer in in vivo experiment. PWS (200 mg / kg) also augmented the anti-inflammatory effect of indomethacin in 1% carrageen-induced foot swelling in rat. Finally, pharmacokinetic study revealed that PWS co-treatment did not influence plasma level of indomethacin. Based on the above results, co-treatment with PWS reduced the occurrence of indomethacin-induced gastric ulcers without affecting the anti-inflammatory effect and the plasma concentration of indomethacin This result demonstrated an useful integration therapy of western and Chinese medicine.
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