The interaction of Indomethacin andPing-wei-san
碩士 === 臺北醫學大學 === 生藥學研究所 === 98 === Indomethacin is one of the commonly used non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis. However,gastric ulcer is a common side effect of this drug. The purpose of this study was to investigate the effect of combined administration o...
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Others |
Language: | zh-TW |
Published: |
2010
|
Online Access: | http://ndltd.ncl.edu.tw/handle/09340810986829768934 |
id |
ndltd-TW-098TMC05553001 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-TW-098TMC055530012015-10-13T13:43:20Z http://ndltd.ncl.edu.tw/handle/09340810986829768934 The interaction of Indomethacin andPing-wei-san Indomethacin與平胃散相互作用之探討 Hsiang-Yin Liu 劉湘吟 碩士 臺北醫學大學 生藥學研究所 98 Indomethacin is one of the commonly used non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis. However,gastric ulcer is a common side effect of this drug. The purpose of this study was to investigate the effect of combined administration of indomethacin with Ping-wei san (PWS), a commonly used traditional Chinese medicine for the treatment of gastrointestinal disease, on reducing the side effects of indomethacin without affecting its efficacy. Indomethacin (0.5 mM) was used to induce gastric mucosal cell injury and gastric ulcer. Co-administration of PWS (0.625 ~ 2.5 mg / ml) resulted in a dose-dependent inhibition of indomethacin-induced gastric mucosal cell toxicity. PWS (200 mg / kg) could also reduce the indomethacin (40 mg / kg)-induced gastric ulcer in in vivo experiment. PWS (200 mg / kg) also augmented the anti-inflammatory effect of indomethacin in 1% carrageen-induced foot swelling in rat. Finally, pharmacokinetic study revealed that PWS co-treatment did not influence plasma level of indomethacin. Based on the above results, co-treatment with PWS reduced the occurrence of indomethacin-induced gastric ulcers without affecting the anti-inflammatory effect and the plasma concentration of indomethacin This result demonstrated an useful integration therapy of western and Chinese medicine. 王靜瓊 2010 學位論文 ; thesis 60 zh-TW |
collection |
NDLTD |
language |
zh-TW |
format |
Others
|
sources |
NDLTD |
description |
碩士 === 臺北醫學大學 === 生藥學研究所 === 98 === Indomethacin is one of the commonly used non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis. However,gastric ulcer is a common side effect of this drug. The purpose of this study was to investigate the effect of combined administration of indomethacin with Ping-wei san (PWS), a commonly used traditional Chinese medicine for the treatment of gastrointestinal disease, on reducing the side effects of indomethacin without affecting its efficacy. Indomethacin (0.5 mM) was used to induce gastric mucosal cell injury and gastric ulcer. Co-administration of PWS (0.625 ~ 2.5 mg / ml) resulted in a dose-dependent inhibition of indomethacin-induced gastric mucosal cell toxicity. PWS (200 mg / kg) could also reduce the indomethacin (40 mg / kg)-induced gastric ulcer in in vivo experiment. PWS (200 mg / kg) also augmented the anti-inflammatory effect of indomethacin in 1% carrageen-induced foot swelling in rat. Finally, pharmacokinetic study revealed that PWS co-treatment did not influence plasma level of indomethacin. Based on the above results, co-treatment with PWS reduced the occurrence of indomethacin-induced gastric ulcers without affecting the anti-inflammatory effect and the plasma concentration of indomethacin This result demonstrated an useful integration therapy of western and Chinese medicine.
|
author2 |
王靜瓊 |
author_facet |
王靜瓊 Hsiang-Yin Liu 劉湘吟 |
author |
Hsiang-Yin Liu 劉湘吟 |
spellingShingle |
Hsiang-Yin Liu 劉湘吟 The interaction of Indomethacin andPing-wei-san |
author_sort |
Hsiang-Yin Liu |
title |
The interaction of Indomethacin andPing-wei-san |
title_short |
The interaction of Indomethacin andPing-wei-san |
title_full |
The interaction of Indomethacin andPing-wei-san |
title_fullStr |
The interaction of Indomethacin andPing-wei-san |
title_full_unstemmed |
The interaction of Indomethacin andPing-wei-san |
title_sort |
interaction of indomethacin andping-wei-san |
publishDate |
2010 |
url |
http://ndltd.ncl.edu.tw/handle/09340810986829768934 |
work_keys_str_mv |
AT hsiangyinliu theinteractionofindomethacinandpingweisan AT liúxiāngyín theinteractionofindomethacinandpingweisan AT hsiangyinliu indomethacinyǔpíngwèisànxiānghùzuòyòngzhītàntǎo AT liúxiāngyín indomethacinyǔpíngwèisànxiānghùzuòyòngzhītàntǎo AT hsiangyinliu interactionofindomethacinandpingweisan AT liúxiāngyín interactionofindomethacinandpingweisan |
_version_ |
1717741442492792832 |