| Summary: | 碩士 === 國立陽明大學 === 臨床牙醫學研究所 === 98 === Adding Chlorhexidine (CHX) into glass ionomer cement (GI) has been proved to possess antibacterial benefit. Most of related researches have postulated that 1% CHX added in GI could be applied optimally for clinical use. Regarding to the cell toxicity of CHX itself and other effects that may negatively influence GI, it is worthy to reappraise the optimal concentration of CHX in GI. This study investigated the use of an experimental GIC as a carrier for the release of CHX diacetate at concentrations of 0.5%, 1%, 2%, respectively, of CHX diacetate by w/w as experimental groups. GI without CHX diacetate was used as control. The optimal concentration of CHX in GI was verified by means of antibacterial test, cell toxicity test, diametral tensile strength, surface microhardness tests, fluoride ion release test, the color stability test, wear resistance tests and scanning electron microscopy observation. The results showed that with the increasing concentration of CHX diacetate the cell toxicity, antibacterial ability and color difference were increased. While, diametral tensile strength, microhardness, wear resistance and fluoride release ability were decreased. Although adding CHX diacetate in GI had antibacterial effect to both S. mutans and A. actinomycetemcomitans, but it also demonstrated significant adverse effects on cytotoxicity and wear resistant. We suggested that GI containing CHX should be used as the base material in sandwich technique, and only 0.5% CHX modified GI could be used to restore the class V cavity in patient with mild periodontitis.
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