Enantioseparation of phenylglycinol by distillative freezing
碩士 === 長庚大學 === 化工與材料工程學系 === 99 === Distillative freezing (DF) is a new separation technique which combines distillation and crystallization to produce pure crystals. In principle, DF is operated at a triple-point condition, in which the liquid mixture is simultaneously vaporized and crystallized d...
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2011
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| Online Access: | http://ndltd.ncl.edu.tw/handle/61367623570773172552 |
| Summary: | 碩士 === 長庚大學 === 化工與材料工程學系 === 99 === Distillative freezing (DF) is a new separation technique which combines distillation and crystallization to produce pure crystals. In principle, DF is operated at a triple-point condition, in which the liquid mixture is simultaneously vaporized and crystallized due to the three-phase equilibrium. The process is continued until the liquid phase is completely eliminated and only the pure solid crystals remain in the feed. Thus, crystal washing is not required since no impurities are adhered on the crystal surfaces at the end of DF.
This study is to apply DF for phenylglycinol enantiomers separation. A thermodynamic model is developed to simulate the three-phase equilibrium during the DF operation. Various operating pressure are also adopted during the temperature-decreasing to simulate the actual three-phase equilibrium conditions. The experiments show the R-phenylglycinol can be purified from 95% to 96% with the recovery 82%, or from 97% to 98% with the recovery rate 87% with magnetic stirring. The purity of final obtained R-phenylglycinol crystals decreases with increasing operating pressure while the recovery rate increases with increasing operating pressure.
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