Effects of Auricularia Polytricha Extracts on Improving Liver in Rats with Nonalcoholic Fatty Liver Disease

• Main Authors: Yu-Hsuan Chou, 周育瑄
• Other Authors: 楊惠婷
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/47773967035746774146

碩士 === 中國醫藥大學 === 營養學系碩士班 === 99 === The pathology leading to non-alcoholic steatohepatitis (NASH) is often characterized by the “two-hit” theory. The “first-hit” is triggered with obesity and insulin resistance, which causes excess hepatic lipid accumulation and hepatic steatosis. The steatotic liver is vulnerable to “second-hits,” which was mediated by inflammation and oxidative stress, resulting in lipid peroxidation then NASH. Auricularia polytricha is found to have therapeutic effects, including anti-inflammatory, antitumor, hypercholesterolemia, etc. The purpose of the study was to examine whether Auricularia polytricha extract （APE） improved liver damage in the animal model of NASH. 40 Male Sprague Dawley rats were randomly divided into five groups. Except the normal and high fat control group (control, HFD group), the experimental groups were fed with high fat diet for 8 weeks then divided into three groups by different amount of APE supplementation (0, 0.5, 1.5%) for 4 weeks. After 12 weeks of treatment, animals were sacrificed; blood samples and liver tissues were collected immediately for biological analysis. The results show that 1.5% APE significantly lowered plasma AST and ALT level and ameliorated hepatic steatosis and necroinflammation; In the first hit, APE improved the dyslipidemia, liver lipid metabolism and plasma free fatty acid level, as well as increased insulin sensitivity; In the aspect of second hit, 1.5% APE decreased the plasma and hepatic MDA content, liver inflammatory response then improved the antioxidant status. In conclusion, APE presents an effective improvement on liver damage of nonalcoholic steatohepatitis model.