ADC Analysis of Parotid Gland of Sjorgren’s Syndrome Response to Cevimeline Treatment

• Main Authors: Ming-Chi, 吳明基
• Other Authors: James Cheng-Chung Wei
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/71979252129620057018

碩士 === 中山醫學大學 === 醫學研究所 === 99 === Background and Purpose: Sjögren''s Syndrome (SS) is considered a systemic autoimmune disease with the exocrine glands as main target organs. The purpose of this study is using ADC to analysis of the parotid gland of Sjögren''s syndrome response to cevimeline treatment. Material and Method: Total 36 subjects with Sjögren’s syndrome presented with xerostomia were enrolled. Initial MR imaging was performed before treatment, and perofromed 2nd MR study after 4 weeks of proper cevimeline treatment. Result: Regarding response to salivary stimulation, there was a significant increase the mean ADC values on pre-cevimeline treatment. Also significant increase the mean ADC values on post-cevimeline treatment. After 4 weeks cevimeline treatment, the salivary secretion respone revealing significant increase from 5.3% increase to 11.3%. Discussion : Our results show that significant increase ADC values after salivary stimulation, which suggest that ADC values can be a monitor of salivary secretion. The salivary secretion respone revealing significant increase, which suggest that cevimeline treatment can increase sensitivity of salivary secretion stimulation in Sjogren patient even only 4 weeks follow up. However, this increase in secretion may be transient. Conclusion: ADC values can be a monitor of salivary secretion. DWI able to evaluate response sensitivity of salivary flow of the Sjogren syndrome in post cevimeline treatment.