In vitro physicochemical properties of biodegradable calcium silicate-based composite cements for bone tissue engineering

• Main Authors: Nai-Shuo, 薛乃碩
• Other Authors: Shinn-Jyh Ding
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/64458292656428840462

碩士 === 中山醫學大學 === 口腔材料科學研究所 === 99 === The scaffold is the temporary supporting structure of tissue-engineered constructions. The objective of this study was to investigate the properties of calcium silicate/calcium sulfate/ gelatin composite cements for bone tissue engineering applications. The results showed that with the addition of calcium sulfate to calcium silicate, the increased diametral tensile strength values (2.4−3.1 MPa) and shortened setting time (7-25 min) of the cements were found; however, calcium sulfate resulted to the reduces antibacterial activity. Besides, the presence of gelatin microspheres appreciably improved the anti-washout capacity. When soaking in simulated body fluid (SBF) for 1 day, the precipitation of apatite particles for the control group without calcium sulfate was faster than the composite cements. After 180 days of soaking, weight loss for the cement specimens containing 0 and 60 wt% calcium sulfate were 18 and 38%, respectively. The corresponding diametral tensile strength values became 1.6 and 0.98 MPa after soaking for 180 days. Calcium sulfate could promote the degradation of calcium silicate-based cements and gelatin inproved anti-washout properties. The novel composite cement may be a potential candidate for bone tissue engineering.