Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna

• Main Authors: Yu-Hsuan Yang, 楊于萱
• Other Authors: Ian-Lih Tsai
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/96714024877308659344

碩士 === 高雄醫學大學 === 天然藥物研究所 === 99 === Cryptocarya concinna Hance (syn.: Cryptocarya konishii Hayata ex Kawakami; Lauraceae) are medium-sized evergreen trees, which distributed in south China and Taiwan. In our studies on the antitubercular constituents of Formosan plants, many species have been screened for in vitro antitubercular activity, and C. concinna has been found to be one of the active species. Investigation of the EtOAc-soluble fraction of the stems of C. concinna has led to the isolation of five new compounds, including one chalcone, concicryptol (1), one isocoumarin, concinol (2), and three flavanones, mixtures of cryptoflavanonic acids?nA (3) and?nB (4), 5-dehyrocryptoflavanone A (5), along with 17 known compounds, comprising of two chalcones: cryptocaryone (18) and infectocaryone (95), three isocoumarins: 5-chloro-8-hydroxy-6-methoxy-3- methylisocoumarin (6), 8-hydroxy-6,7-dimethoxy-3-methylisocoumarin (10)、5-methylmellein (15), seven flavanones, cryptoflavanones C?n?v8?w, cryptoflavanones D?n?v9?w, cryptoflavanone A (11), cryptoflavanone B (12), pinostrobin (14), cryptocaryanone A (97) and cryptochinone B (163), three steroids: mixtures of ??-sitosterol (77) and stigmasterol (175), ??-sitostenone (174), one benzenoid: methyl cinnamate (13) and one fatty acid: stearic acid (16). The structures of these isolates were determined through spectral analyses and comparison of their physical and spectral data with literatures. In the in vitro antitubercular activity assay of these isolates, compounds 1, 18, 95, 97 and 163 exhibited antitubercular activities with their MIC values of 10.0、10.5、12.0、8.0 and 15.0 mg/mL, respectively.