Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna
碩士 === 高雄醫學大學 === 天然藥物研究所 === 99 === Cryptocarya concinna Hance (syn.: Cryptocarya konishii Hayata ex Kawakami; Lauraceae) are medium-sized evergreen trees, which distributed in south China and Taiwan. In our studies on the antitubercular constituents of Formosan plants, many species have been scree...
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ndltd-TW-099KMC050680172015-10-13T20:37:29Z http://ndltd.ncl.edu.tw/handle/96714024877308659344 Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna 台灣產土楠莖部化學及生物活性成分之研究 Yu-Hsuan Yang 楊于萱 碩士 高雄醫學大學 天然藥物研究所 99 Cryptocarya concinna Hance (syn.: Cryptocarya konishii Hayata ex Kawakami; Lauraceae) are medium-sized evergreen trees, which distributed in south China and Taiwan. In our studies on the antitubercular constituents of Formosan plants, many species have been screened for in vitro antitubercular activity, and C. concinna has been found to be one of the active species. Investigation of the EtOAc-soluble fraction of the stems of C. concinna has led to the isolation of five new compounds, including one chalcone, concicryptol (1), one isocoumarin, concinol (2), and three flavanones, mixtures of cryptoflavanonic acids?nA (3) and?nB (4), 5-dehyrocryptoflavanone A (5), along with 17 known compounds, comprising of two chalcones: cryptocaryone (18) and infectocaryone (95), three isocoumarins: 5-chloro-8-hydroxy-6-methoxy-3- methylisocoumarin (6), 8-hydroxy-6,7-dimethoxy-3-methylisocoumarin (10)、5-methylmellein (15), seven flavanones, cryptoflavanones C?n?v8?w, cryptoflavanones D?n?v9?w, cryptoflavanone A (11), cryptoflavanone B (12), pinostrobin (14), cryptocaryanone A (97) and cryptochinone B (163), three steroids: mixtures of ??-sitosterol (77) and stigmasterol (175), ??-sitostenone (174), one benzenoid: methyl cinnamate (13) and one fatty acid: stearic acid (16). The structures of these isolates were determined through spectral analyses and comparison of their physical and spectral data with literatures. In the in vitro antitubercular activity assay of these isolates, compounds 1, 18, 95, 97 and 163 exhibited antitubercular activities with their MIC values of 10.0、10.5、12.0、8.0 and 15.0 mg/mL, respectively. Ian-Lih Tsai 蔡烟力 2011 學位論文 ; thesis 176 zh-TW |
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碩士 === 高雄醫學大學 === 天然藥物研究所 === 99 === Cryptocarya concinna Hance (syn.: Cryptocarya konishii Hayata ex Kawakami; Lauraceae) are medium-sized evergreen trees, which distributed in south China and Taiwan. In our studies on the antitubercular constituents of Formosan plants, many species have been screened for in vitro antitubercular activity, and C. concinna has been found to be one of the active species. Investigation of the EtOAc-soluble fraction of the stems of C. concinna has led to the isolation of five new compounds, including one chalcone, concicryptol (1), one isocoumarin, concinol (2), and three flavanones, mixtures of cryptoflavanonic acids?nA (3) and?nB (4), 5-dehyrocryptoflavanone A (5), along with 17 known compounds, comprising of two chalcones: cryptocaryone (18) and infectocaryone (95), three isocoumarins: 5-chloro-8-hydroxy-6-methoxy-3- methylisocoumarin (6), 8-hydroxy-6,7-dimethoxy-3-methylisocoumarin (10)、5-methylmellein (15), seven flavanones, cryptoflavanones C?n?v8?w, cryptoflavanones D?n?v9?w, cryptoflavanone A (11), cryptoflavanone B (12), pinostrobin (14), cryptocaryanone A (97) and cryptochinone B (163), three steroids: mixtures of ??-sitosterol (77) and stigmasterol (175), ??-sitostenone (174), one benzenoid: methyl cinnamate (13) and one fatty acid: stearic acid (16). The structures of these isolates were determined through spectral analyses and comparison of their physical and spectral data with literatures.
In the in vitro antitubercular activity assay of these isolates, compounds 1, 18, 95, 97 and 163 exhibited antitubercular activities with their MIC values of 10.0、10.5、12.0、8.0 and 15.0 mg/mL, respectively.
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author2 |
Ian-Lih Tsai |
author_facet |
Ian-Lih Tsai Yu-Hsuan Yang 楊于萱 |
author |
Yu-Hsuan Yang 楊于萱 |
spellingShingle |
Yu-Hsuan Yang 楊于萱 Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna |
author_sort |
Yu-Hsuan Yang |
title |
Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna |
title_short |
Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna |
title_full |
Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna |
title_fullStr |
Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna |
title_full_unstemmed |
Chemical Constituents and Biological Activities from the Stems of Formosan Cryptocarya concinna |
title_sort |
chemical constituents and biological activities from the stems of formosan cryptocarya concinna |
publishDate |
2011 |
url |
http://ndltd.ncl.edu.tw/handle/96714024877308659344 |
work_keys_str_mv |
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