| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 99 === This thesis describes the synthesis and antiproliferative evaluation of quinolinylchalcone derivatives. A number of 3-substituted phenylquinolinylchalcones were synthesized by the condensation of 3-(4-substituted phenyl)quinoline-2-carbaldehydes and substituted acetophenones in a fairly good yields. These newly synthesized compounds were evaluated for their antiproliferative activities against lung caners (A549, H1299, and H460), breast cancers (MCF-7, MB-231, and SKBR-3), and normal cell lines (MRC-5 and M10). Results of this study indicated that most of these target compounds exhibited potent antiproliferative activities. Among them, the introduction of methoxy group at the para-position of 3-phenyl group and the introduction of para-aminoalkoxy or 3,4,5-trimethoxyphenyl group at the C-2 position significantly enhanced antiproliferative selectivity against H1299 cell line.
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