Effects of cyclooxygenase inhibitors on homocysteine metabolism
碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 99 === Abstract Recent clinical trials have linked non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors to an increased risk of cardiovascular events. Abnormal homocysteine level is a known risk factor for ca...
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ndltd-TW-099NCHU52530022016-10-23T04:11:19Z http://ndltd.ncl.edu.tw/handle/76807960357106668144 Effects of cyclooxygenase inhibitors on homocysteine metabolism 環氧化酶抑制劑止痛藥對同半胱胺酸代謝影響之相關研究 Yan-Jun Lin 林彥君 碩士 國立中興大學 食品暨應用生物科技學系所 99 Abstract Recent clinical trials have linked non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors to an increased risk of cardiovascular events. Abnormal homocysteine level is a known risk factor for cardiovascular diseases. The aim of this study was to investigate the impacts of cyclooxygenase (COX) inhibitors on homocysteine metabolism. We conducted a one month follow-up clinical study to investigate the impacts of selective and non-selective COX inhibitor on plasma homocysteine levels. An animal study was also performed to investigate the impacts of long-term COX inhibitors on homocysteine metabolism in vivo. The concentrations of total homocysteine and its related metabolites were determined in different tissues. Data from the present study demonstrated that clinical use of COX inhibitors altered homocysteine metabolism in a tissue specific manner. Kinetic studies on the homocysteine transmethylation fluxes in COX inhibitor treatments are underway. 蔣恩沛 2011 學位論文 ; thesis 27 en_US |
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碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 99 === Abstract
Recent clinical trials have linked non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors to an increased risk of cardiovascular events. Abnormal homocysteine level is a known risk factor for cardiovascular diseases. The aim of this study was to investigate the impacts of cyclooxygenase (COX) inhibitors on homocysteine metabolism. We conducted a one month follow-up clinical study to investigate the impacts of selective and non-selective COX inhibitor on plasma homocysteine levels. An animal study was also performed to investigate the impacts of long-term COX inhibitors on homocysteine metabolism in vivo. The concentrations of total homocysteine and its related metabolites were determined in different tissues. Data from the present study demonstrated that clinical use of COX inhibitors altered homocysteine metabolism in a tissue specific manner. Kinetic studies on the homocysteine transmethylation fluxes in COX inhibitor treatments are underway.
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author2 |
蔣恩沛 |
author_facet |
蔣恩沛 Yan-Jun Lin 林彥君 |
author |
Yan-Jun Lin 林彥君 |
spellingShingle |
Yan-Jun Lin 林彥君 Effects of cyclooxygenase inhibitors on homocysteine metabolism |
author_sort |
Yan-Jun Lin |
title |
Effects of cyclooxygenase inhibitors on homocysteine metabolism |
title_short |
Effects of cyclooxygenase inhibitors on homocysteine metabolism |
title_full |
Effects of cyclooxygenase inhibitors on homocysteine metabolism |
title_fullStr |
Effects of cyclooxygenase inhibitors on homocysteine metabolism |
title_full_unstemmed |
Effects of cyclooxygenase inhibitors on homocysteine metabolism |
title_sort |
effects of cyclooxygenase inhibitors on homocysteine metabolism |
publishDate |
2011 |
url |
http://ndltd.ncl.edu.tw/handle/76807960357106668144 |
work_keys_str_mv |
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