Effects of cyclooxygenase inhibitors on homocysteine metabolism

• Main Authors: Yan-Jun Lin, 林彥君
• Other Authors: 蔣恩沛
• Format: Others
• Language: en_US
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/76807960357106668144

碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 99 === Abstract Recent clinical trials have linked non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors to an increased risk of cardiovascular events. Abnormal homocysteine level is a known risk factor for cardiovascular diseases. The aim of this study was to investigate the impacts of cyclooxygenase (COX) inhibitors on homocysteine metabolism. We conducted a one month follow-up clinical study to investigate the impacts of selective and non-selective COX inhibitor on plasma homocysteine levels. An animal study was also performed to investigate the impacts of long-term COX inhibitors on homocysteine metabolism in vivo. The concentrations of total homocysteine and its related metabolites were determined in different tissues. Data from the present study demonstrated that clinical use of COX inhibitors altered homocysteine metabolism in a tissue specific manner. Kinetic studies on the homocysteine transmethylation fluxes in COX inhibitor treatments are underway.