Mechanism of Copper complexes as catalysts for C-O coupling reactions

• Main Authors: Hong-Jie Chen, 陳弘杰
• Other Authors: Shin-Guang Shyu
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/48483361988562483491

碩士 === 國立中央大學 === 化學研究所 === 99 === C-O coupling reactions are widely used in natural products and materials synthesis, thus, in recent decades, scientists have reported numerous articles. In this article, we used copper as the transition metal to do catalytic reactions were carried out in four conditions which were CuI/phen/K2CO3, CuI/K2CO3, CuI/phen/Cs2CO3, CuI/Cs2CO3. After that we hope to find the intermediate of catalytic reactions and then confirm the reaction paths, thus, our lab choose to use the ESI-MS. Finally, comparing the selectivity of 4-bromotoluene and 2-bromotoluene confirmed the structures we measured by ESI-MS. We found that most scientists speculated the intermediate (phen)Cu(OR) doesn’t necessarily belong to the main catalytic reaction paths as starting structure.