Studies on the Secondary Metabolites from the Soft CoralLobophytum durum

• Main Authors: Hwa-Pyng Chen, 陳華平
• Other Authors: Chang-Yih Duh
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/37026099383162021006

碩士 === 國立中山大學 === 海洋生物科技暨資源學系研究所 === 99 === Soft corals of the genus Lobophytum (Alcyoniidae) have been well recognized as a rich source of various secondary metabolites that have attracted much interest for the natural products chemists due to their structural complexity and remarkable pharmacological activities such as cytotoxicity, antibacterial activities, anti-inflammatory properties, and antiviral activity. Twelve cembrane diterpenes including six new secondary metabolites 1−6 were isolated organic extracts of soft coral Lobophytum durum collected at Dongsha Atolls. The structures of these six new cembranolides were determined by 1H, 13C, DEPT, COSY, HMBC, HSQC, NOESY, IR and Mass spectra. Furthermore, these six new secondary metabolites 1−6 were evaluated in vitro for the cytotoxicity against A-459 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines, and antiviral activity against HCMV (human cytomegalovirus) cells.