Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone
碩士 === 國立清華大學 === 化學系 === 99 === In this thesis, we investigate the synthesis of the core structure 66 of the natural products xestoquinone (1) and halenaquinone (3). First, we chose enone 69 as starting material, which underwent oxidations, iodination and O-alkylation with side chain 84 afforded...
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2011
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| Online Access: | http://ndltd.ncl.edu.tw/handle/16393620635425083403 |
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ndltd-TW-099NTHU50650842015-10-13T20:23:00Z http://ndltd.ncl.edu.tw/handle/16393620635425083403 Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone 天然物Xestoquinone和Halenaquinone全合成之關鍵中間體的合成研究 Ho, Jung-Chieh 何榮傑 碩士 國立清華大學 化學系 99 In this thesis, we investigate the synthesis of the core structure 66 of the natural products xestoquinone (1) and halenaquinone (3). First, we chose enone 69 as starting material, which underwent oxidations, iodination and O-alkylation with side chain 84 afforded compound 68. The compound 67 was obtained via intramolecluar radical cyclization, and then followed by aromatization to give diene 86. Finally, the crucial intermediate 66 was obtained by ring closing metathesis using catalyst 92. The total yield from enone 69 to compound 66 is 19.3%. In the future, compound 66 could be used for the total synthesis of xestoquinone (1) and halenaquinone (3) 沙晉康 2011 學位論文 ; thesis 58 zh-TW |
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zh-TW |
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碩士 === 國立清華大學 === 化學系 === 99 === In this thesis, we investigate the synthesis of the core structure 66 of the natural products xestoquinone (1) and halenaquinone (3). First, we chose enone 69 as starting material, which underwent oxidations, iodination and O-alkylation with side chain 84 afforded compound 68. The compound 67 was obtained via intramolecluar radical cyclization, and then followed by aromatization to give diene 86. Finally, the crucial intermediate 66 was obtained by ring closing metathesis using catalyst 92. The total yield from enone 69 to compound 66 is 19.3%. In the future, compound 66 could be used for the total synthesis of xestoquinone (1) and halenaquinone (3)
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| author2 |
沙晉康 |
| author_facet |
沙晉康 Ho, Jung-Chieh 何榮傑 |
| author |
Ho, Jung-Chieh 何榮傑 |
| spellingShingle |
Ho, Jung-Chieh 何榮傑 Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone |
| author_sort |
Ho, Jung-Chieh |
| title |
Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone |
| title_short |
Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone |
| title_full |
Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone |
| title_fullStr |
Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone |
| title_full_unstemmed |
Synthesis of the Key Intermediate for Total Synthesis of Xestoquinone and Halenaquinone |
| title_sort |
synthesis of the key intermediate for total synthesis of xestoquinone and halenaquinone |
| publishDate |
2011 |
| url |
http://ndltd.ncl.edu.tw/handle/16393620635425083403 |
| work_keys_str_mv |
AT hojungchieh synthesisofthekeyintermediatefortotalsynthesisofxestoquinoneandhalenaquinone AT héróngjié synthesisofthekeyintermediatefortotalsynthesisofxestoquinoneandhalenaquinone AT hojungchieh tiānránwùxestoquinonehéhalenaquinonequánhéchéngzhīguānjiànzhōngjiāntǐdehéchéngyánjiū AT héróngjié tiānránwùxestoquinonehéhalenaquinonequánhéchéngzhīguānjiànzhōngjiāntǐdehéchéngyánjiū |
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1718046721524629504 |