| Summary: | 碩士 === 國立臺灣科技大學 === 工程技術研究所 === 99 === Mesoporous silica materials have been developed rapidly in recent years in that these materials have several newly-found advantages, namely, the steady, uniform mesoporous structure, high surface area, adjustable narrow distribution of pore sizes, easily- modified surface properties, non-toxicity and good biocompatibility. These characteristics equip the mesoporous silica materials with very good applications of biomedical materials.
Mesoporous bioactive glass was published in 2005. This material combined mesoporous material with bioactive glasses, making it easier to form Hydroxyapatite in bone tissue. Therefore, the bioactivity is higher than common mesoporous silicon materials. As a drug delivery system, the walls silanol groups can be functionalized to achieve the aim of controlling drug release rate. The characteristics described above are all important conditions for mesoporous bioactive glasses to be used as bone repair materials.
This project employs the medicine, ibuprofen, as guest molecules to store and Vinyltrimethoxysilane for the sealant to be utilized into the surface functionalization reactions. Studying the different relationships between altering the amount of Vinyltrimethoxysilane and its effect on the drug release rate can provide more supporting ideas to discuss if they can be proper carriers in body therapy.
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