Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents
碩士 === 東海大學 === 化學系 === 99 === This thesis reports the solid-phase synthesis of seven peptides containing 4-amino-1-pyrrole-2-carboxylic acid residues (Py), two novel cyclic peptides, and nine chlorambucil-peptide conjugates. A new 2,6-dimethoxyhydroquinone- 3-mercaptoacetic acid-dipeptide conjugate...
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ndltd-TW-099THU000650032015-10-13T19:06:46Z http://ndltd.ncl.edu.tw/handle/12747323697796342835 Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents 新DNA結合胜肽及DNA切割劑之合成 Fun Shu Ting 范淑亭 碩士 東海大學 化學系 99 This thesis reports the solid-phase synthesis of seven peptides containing 4-amino-1-pyrrole-2-carboxylic acid residues (Py), two novel cyclic peptides, and nine chlorambucil-peptide conjugates. A new 2,6-dimethoxyhydroquinone- 3-mercaptoacetic acid-dipeptide conjugate was also synthesized. Agarose gel electrophoresis was used to determine the gel retardation and DNA cleavage abilities of these compounds, revealing that a number of these new synthetic peptides and conjugates display good DNA binding and DNA cleavage activities. Electron paramagnetic resonance (EPR) showed that the new quinone conjugate DWRO readily produces strong semiquinone radicals that are ultra-stable and has DNA cleavage activity. 佘亮 2011 學位論文 ; thesis 117 zh-TW |
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碩士 === 東海大學 === 化學系 === 99 === This thesis reports the solid-phase synthesis of seven peptides containing 4-amino-1-pyrrole-2-carboxylic acid residues (Py), two novel cyclic peptides, and nine chlorambucil-peptide conjugates. A new 2,6-dimethoxyhydroquinone- 3-mercaptoacetic acid-dipeptide conjugate was also synthesized. Agarose gel electrophoresis was used to determine the gel retardation and DNA cleavage abilities of these compounds, revealing that a number of these new synthetic peptides and conjugates display good DNA binding and DNA cleavage activities. Electron paramagnetic resonance (EPR) showed that the new quinone conjugate DWRO readily produces strong semiquinone radicals that are ultra-stable and has DNA cleavage activity.
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佘亮 |
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佘亮 Fun Shu Ting 范淑亭 |
author |
Fun Shu Ting 范淑亭 |
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Fun Shu Ting 范淑亭 Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents |
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Fun Shu Ting |
title |
Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents |
title_short |
Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents |
title_full |
Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents |
title_fullStr |
Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents |
title_full_unstemmed |
Synthesis of Novel DNA Binding Peptides and DNA-cleavage Agents |
title_sort |
synthesis of novel dna binding peptides and dna-cleavage agents |
publishDate |
2011 |
url |
http://ndltd.ncl.edu.tw/handle/12747323697796342835 |
work_keys_str_mv |
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1718041327575236608 |