Berberine Inhibits Metastatic Potential of Ovarian Cancer Cells via PI3K/Akt Signaling Pathway

• Main Authors: Kuo-Hui Wu, 吳國暉
• Other Authors: Tzu-Chao Chuang
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/04107753842688707418

碩士 === 淡江大學 === 化學學系碩士班 === 99 === Berberine, one of the effective anti-cancer components of Coptis Chinensis, is a type of isoquinoline alkaloid. It has been reported various anti-cancer effects in different human cancer cell lines. Other research reported that berberine inhibited migration and invasion via MAPK pathways of human tongue cancer cells. Here, we reported that berberine inhibits cell proliferation, migration, invasion and angiogenesis of human ovarian cancer cell lines. The effects were mediated through inhibiting EGFR and HER2/neu expression and their down-stream signalings such as PI3K/Akt signaling pathway resulting in inhibition of MMP-2, VEGF and cyclin D1 protein. We discovered a novel therapeutic approach of anti-cancer role of berberine.