| Summary: | 碩士 === 國立陽明大學 === 醫學工程研究所 === 99 === The aim of this research was to develop a novel contrast agent with ultrasound and magnetic resonance (MR) imaging contrast with ultrasonically triggered drug release behavior. This multi-functional vehicle was composed of CHC-Fe3O4 micelles, a drug carrier containing an MRI contrast agent, and bovine serum albumin (BSA) microbubbles through the electrostatic interaction (i.e., MB@CHC-Fe3O4). The structure and magnetic property of MB@CHC-Fe3O4 was characterized via using transmission electron microscopy (TEM), X-ray diffraction (XRD) and superconducting quantum interference device (SQUID) Subsequently, the ultrasound-induced release, ultrasound imaging and magnetic resonance imaging of MB@CHC-Fe3O4 were systemically carried out. It was found that the drug encapsulated in the MB@CHC-Fe3O4 could be released after therapeutic ultrasound (1 MHz) triggering. Besides, after ultrasound triggering and drug release, the morphology of vehicles and the r2 - r2* value were altered. In addition,the in vitro and in vivo ultrasonography indicated that cross-linking process for microbubbles could increase the circulation life of the
vehicles in the rat body. Furthermore, the ultrasound signal intensity of the MB@CHC-Fe3O4 was higher than that of microbubbles. It is suggested that the MB@CHC-Fe3O4 could be used not only as an MR-guided drug vehicle of ultrasonically triggered release but also an MR reporter to probe ultrasonically triggered drug release.
|
|---|
